In the present investigation, bi-layer tablets containing Olmesartans Medoxomil as calcium channel blocker and Metoprolol Succinate as beta blocker were formulated in which tablets containing Olmesartan Medoxomil designed to release immediately while release rate of tablets containing Metoprolol Succinate were retarded. Immediate release attributed due to presence of sodium starch glycolate ranging from 2 to 4 % while xanthan gum in concentration from 30 to 35% and Hydroxyl propyl methyl cellulose K15M in concentration from 25 to 30% in different tablet formulations responsible for retard the release of Metoprolol Succinate. Amount of sodium starch glycolate, xanthan gum and Hydroxyl propyl methyl cellulose K15M were optimized to achieve desire release profile.
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